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DISTEK Dissolution and Pharmaceutical Test Instruments


Distek Opt-Diss 410

In-Situ Fiber Optic UV Testing: Dissolution Testing Has Never Been Easier!


No more sampling! Save time, labour and money with the Opt-Diss 410 by making your dissolution lab more efficient while simultaneously giving more information than previously possible.

The Opt-Diss 410 measures directly in the vessel, eliminating tubing, filtering and other issues associated with conventional sampling. Moving light into the vessel rather than pumping the liquid out allows for near real-time  data acquisitions and nearly limitless sample points (up to 1200 time points). All while requiring no complicated manifolds, media return, or tedious volume correction calculations.

  • Simplest, Most Efficient Dissolution Testing
    Ease of system setup and the near real-time dissolution data  acquisition means the complete dissolution report  only takes as long as the actual dissolution run.

  • Rapid Data Collection
    Acquisition speeds as fast as 5 seconds for all  vessels.

  • Routine Collection of Complete Profiles
    Collecting near real-time dissolution profiles is ideal for formulators to understand complicated release dynamics as it occurs.

  • Multicomponent Analysis Software
    The use of state of the art software makes it possible to easily quantify two components at once, without the need for chromatographic separation.  This means the speed and ease UV measurement can now be applied to an even broader class of products with two APIs or  interfering component like excipients, coatings, capsules, etc., without the need for time consuming HPLC analysis.

  • Stationary ARCH Probes
    Designed specifically for dissolution testing, the patented probes virtually eliminate the entrapment of bubbles and particles that plague other fibre systems. The ARCH probes small hydrodynamic cross section also alleviates the need for a complicated raising and lowering sampling manifold.

  • Single Detector with No Moving Parts
    The Opt-Diss 410 uses a scientific 2-D CCD multichannel detector and spectrograph that allow for the acquisition of the entire spectral range (200 to 400 nm) from all vessels simultaneously with one detector. This eliminates the inter-channel variability encountered with multi-detector systems or other single detector systems that require a  multiplexer.

  • Optimized for Distek Baths, but Compatible with Others
    Full system integration and single software control means seamless integration with a Distek dissolution system while still allowing integration with most other brands without the need for additional hardware. 

Application Notes

Opt-Diss 410 White Paper

Analysis of two Active Pharmaceutical Ingredients (API) Products using UV spectrophotometry with Multi-Component Analysis and a Fibre Optic Dissolution Analyser.

Acetaminophen 500mg

In-situ UV fibre-optic measurement of Acetaminophen (500mg) in DI water. 

Dimenhydrinate (50mg)

In-Situ fire-optic measurement of Dimenhydrinate (50mg) in DI water.

Ibuprofen 400mg

In-situ UV fibre-optic measurement of Ibuprofen (400mg) in Phosphate buffer pH7.2. 

Ordering Information, Accessories and Parts
Part Number
Opt-Diss 8-Channel Fiber Optic Dissolution Testing System. Includes Spectrograph, CCD Detector, Dissolution Testing Software and embedded PC with Windows 7 OS.
Opt-Diss 12-Channel Fiber Optic Dissolution Testing System. Includes Spectrograph, CCD Detector, Dissolution Testing Software and embedded PC with Windows 7 OS.
8 Channel Fiber Bundle for Opt-Diss, PVC Cover
12 Channel Fiber Bundle for Opt-Diss, PVC Cover
Attenuator Set for Opt-Diss, Includes 1 Each Pack of 10. Blue (3.6 dB), Gold (5.5 dB), Green (4.3 dB), Red (2.8 dB) and Silver (6.0 dB)
Deuterium Lamp for Opt-Diss
Arch Probe, 1 mm Pathlength
A wide variety of additional configurations and accessories are also available. Please contact us for further details.
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