Inhalation Sciences AB - Breathing New Life into Inhalation R&D
Nose-Only Exposure Module
This nose-only module exposes single rodents, one-at-a-time, to respirable aerosols from PreciseInhale® safely, gently and precisely - reducing standard deviation, the number of test animals needed and obtaining highly reliable pharmacokinetic data.
Nose-only inhalation is a standard method of exposure used in preclinical testing of inhalation drugs as well as inhalation toxicity studies in rodents. This method has the advantage of directed respiratory exposures compared with exposures in whole body chambers.
Using the PreciseInhale® system for nose-only inhalation exposures in vivo allows reducing variability of exposure between animals and substance consumption due to individual active dosing control. Unlike ex vivo experiments in the IPL model, n vivo experiments study the distribution, metabolism and clearance of inhaled drugs in the blood and other tissues following the delivery of a well- controlled dose using the PreciseInhale® system.
Features and Benefits
Precision dosing by active monitoring of aerosol concentration and individual breathing parameters
Individual exposure monitoring & dosing
Low inter-individual variation of exposures
Low substance consumption
Ideal for repeated exposure
Minimized rebreathing of the same aerosol