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Inhalation Sciences AB - Breathing New Life into Inhalation R&D

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PreciseInhale

Inhalation Sciences’ primary product

PreciseInhale® is an advanced laboratory system that lets scientists measure how inhaled particles act in our lungs and affect our health. Today’s standard technologies for this are largely unchanged since the 1950’s, often producing variable, unreliable data. Despite the lung’s impressive ability to get drugs into the body faster and more efficiently than other therapies, developing new inhaled medicines has been held back by poor data that fails to correlate early lab results and later clinical results – a failure that can cost pharma scientists millions in lost investment.

PreciseInhale® changes all that. It delivers results with a proven high correlation between laboratory and human testing – paving the way for more cost-efficient medicines for rapidly-rising global killers like asthma and COPD (chronic obstructive pulmonary disease) —and a new generation of inhaled drugs in broader therapeutic areas, like migraine, impotence, diabetes and influenza. PreciseInhale® is built in modules. It can be tailored closely to the customer’s specific needs. It has been purchased by both pharma scientists developing new treatments, and environmental researchers testing the effects of airborne particle pollutants.

Features and Benefits

  • Precise dosing of the exposure object with the Active Dose Control System 

  • Reproducible, batchwise aerosol generation 

  • Several options for deagglomeration of micronized powders 

  • Aerosol switchboard - flexible configuration possibilities 

  • Repetitive and accurate dosing

  • Minimized standard deviation in between delivered doses 

  • Homogenous aerosols 

  • Even aerosol concentration during the exposure cycle 

  • Aerosol generation of a broad range of dry powders 

  • Same aerosol source throughout the whole development process

  • Low substance consumption

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What is precision dosing?

Researchers precisely tailor their aerosol, setting the dose, and strength of air pressure. This gives control over de-agglomeration and Particle Sized Distribution. Aerosol is generated in a gentle, free-flowing, fine particulate stream easily manageable and producing stable, repeatable data.

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How does it work?

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  1. A jet of high-pressure air is shot through the powder chamber, aerosolising the powder upwards into the holding chamber. The energy of the jet is siphoned off.

  2. The aerosol rises upwards in a plume, then settles downwards in the holding chamber where a controlled air flow ‘pulls’ the API past a real-time monitor.

  3. The real-time aerosol concentration and dose is logged.

  4. The precise exposure is controlled.

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