Drifting or inconsistent Rf values are a common struggle in Thin Layer Chromatography analysis. By understanding and controlling a few hidden variables in the development step in particular, Thin Layer Chromatography (TLC) can be transformed into a reliable, reproducible technique which can be used for so much more than an identification analysis technique. When planning a TLC analysis, the variables which are considered for development are mobile phase composition and development distance....

Effect-Directed Analysis (EDA) is the process of combining fractionation techniques, analytical techniques and bioassays to study unknown active substances or contaminants and their biological effects. Combining a Bioassay with High Performance Thin Layer Chromatography (HPTLC) provides an efficient and inexpensive method of screening for bioactive compounds in complex matrices. HPTLC fingerprints of the crude mushroom extracts and their fractions visualized under four detection conditions....

The dissoWASH&DOSE ® from MEREL Instruments is the latest addition to Omicron's dissolution line-up. A portable, semi-automated vessel washing system to improve the efficiency of the most tedious part of dissolution testing - the washing up! Cleaning the components of a dissolution tester once the test is complete is one of the most time consuming parts of the test for the analyst, it is also crucial to make sure this step is completed thoroughly to prevent contamination between tests. The...