CAMAG TLC MS Interface - rapid extraction of compounds for online transfer into APCI-MS, APPI-MS or ESI-MS

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The elution-based CAMAG TLC-MS Interface 2 is a highly convenient and versatile instrument allowing for rapid and contamination-free elution of TLC/HPTLC zones with online transfer to a mass spectrometer.

Through the pioneering concept of hyphenating high-performance thin-layer chromatography with mass spectrometry unequivocal substance identification is possible. The CAMAG TLC-MS Interface 2 can be installed plug & play with any LC-MS system without adjustments or mass spectrometer modifications. Depending on the MS system, a substance can be identified within a minute via its mass spectrum, or for an unknown substance zone, the respective sum formula can be obtained. Furthermore, interesting zones can be eluted into vials for further investigations with, e.g., NMR, (ATR-)FTIR, ESI-MS, and MALDI-MS.

The chromatogram zones are eluted from the HPTLC plate with methanol or another suitable solvent with the flow speed appropriate for the LC-MS system. The round elution head is used for circular zones and the oval elution head for zones in the form of bands. After extraction the eluate is either transferred online to the mass spectrometer or collected in a sample vial for further offline analysis.

The CAMAG TLC-MS Interface 2 features a modified elution head and an easily accessible, exchangeable filter, arranged in front of the valve. Cleaning is facilitated as compared to the previous version, making it highly efficient. By pushing a button, the elution path is cleaned of matrix particles with compressed air, increasing the lifetime of the filter and preventing the system from becoming blocked. These filters can be easily replaced without any modification to the elution head.

Plate positioning is significantly simplified: together with the positioning scale and the adjustable plate-stopper, the integrated crosshair laser enables accurate and reproducible positioning of the plate. Alternatively the coordinates determined by the CAMAG TLC Visualizer or the CAMAG TLC Scanner can be used to precisely position the HPTLC plate.

Key features

  • Rapid and contamination-free elution of selected zones
  • Online transfer to the mass spectrometer
  • Plug & play installation
  • Compatible with any LC-MS system
  • Confirmation of known substances within a minute
  • Highly effective backwashing function prevents the elution path from becoming blocked
  • Easy handling ensures accurate and reproducible plate positioning
  • Low solvent consumption
Omicron also supply a full range of spares and accessories for all products shown on this website. Please email us with your requirements.


Omicron Research Ltd, Unit 11, Kennet Enterprise Centre, Charnham Lane, Hungerford, Berkshire, RG17 0EY
T: +44 (01488) 682700    F: +44 (01488) 682707   E: sales@omicron-uk.com